About   Help   FAQ
Trp53tm1.2Awbr
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1.2Awbr
Name: transformation related protein 53; targeted mutation 1.2, AW Braithwaite
MGI ID: MGI:5014809
Synonyms: delta122p53
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173271
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Trp53tm1.1Awbr removed exons 3 and 4, which encode the first 122 amino acids (transactivation and proline rich domains). The predicted protein corresponds to human isoform delta133p53 generated from an alternative transript initiation site in intron 4. (J:173271)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  155 strains or lines available
References
Original:  J:173271 Slatter TL, et al., Hyperproliferation, cancer, and inflammation in mice expressing a Delta133p53-like isoform. Blood. 2011 May 12;117(19):5166-77
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/26/2020
MGI 6.15
The Jackson Laboratory