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Targeted Allele Detail
Symbol: Slc25a37tm1.2Kapl
Name: solute carrier family 25, member 37; targeted mutation 1.2, Jerry Kaplan
MGI ID: MGI:5014804
Synonyms: Mfrn1-
Gene: Slc25a37  Location: Chr14:69241848-69285112 bp, - strand  Genetic Position: Chr14, 36.03 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:173284
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site and FRT flanked neomycin selection cassette were inserted in intron 1 and a second loxP site was inserted in intron 2. The selection cassette was subsequently excised by breeding to mice expressing flp recombinase from the Gt(ROSA)26 Sor promoter. This leaves exon2 flanked by loxP sites. Later, cre expression resulted in excision of exon 2. PCR and Western blot analysis confirmed gene inactivation. (J:173284)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc25a37 Mutation:  2 strains or lines available
Original:  J:173284 Troadec MB, et al., Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood. 2011 May 19;117(20):5494-502
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory