Six1^tm1(cre)Xli
Targeted Allele Detail

Summary

• Symbol: Six1^tm1(cre)Xli
• Name: sine oculis-related homeobox 1; targeted mutation 1, Xue Li
• MGI ID: MGI:5014213
• Synonyms: Six1^Cre-hpAP, Six1^Cre/hpAP, Six1^hpAP/Cre, Six1^{tm1(cre,ALPP)Xli}
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm1(cre)Xli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Six1^tm1(cre)Xli expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Six1 (MGI:102780)

• Mutation details: A partial Six1 coding sequence was replaced by homologous recombination with the cre-ALPP (human placenta alkaline phosphatase) sequence linked to an internal ribosomal entry site (IRES)) dicistronic reporter and a PGK-neo selection gene. The allele is a functionally-null allele. (J:172023, J:178455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Six1 (mouse) Summary of all recombinase alleles driven by Six1. Comparative matrix view of recombinase activities Alliance mouse Six1 gene page

Expression

In Mice Carrying this Mutation:

34 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 18 strains or lines available

References

• Original: J:172023 Guo C, et al., A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
• All: 4 reference(s)