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Targeted Allele Detail
Symbol: Pinx1tm1.1Kplu
Name: PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu
MGI ID: MGI:5013947
Gene: Pinx1  Location: Chr14:63860312-63919859 bp, + strand  Genetic Position: Chr14, 33.34 cM, cytoband C3
Varied histopathology of Pinx1tm1.1Kplu/Pinx1+ tumors

Show the 12 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:171997
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR on E9.5 embryo extracts. (J:171997)
Generation of the Pinx1tm1.1Kplu allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pinx1 Mutation:  2 strains or lines available
Original:  J:171997 Zhou XZ, et al., The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest. 2011 Apr 1;121(4):1266-82
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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