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Birc2tm1Rbr
Targeted Allele Detail
Nomenclature
Symbol: Birc2tm1Rbr
Name: baculoviral IAP repeat-containing 2; targeted mutation 1, Robert Brink
MGI ID: MGI:5013654
Synonyms: Birc2flox, cIap1flox
Gene: Birc2  Location: Chr9:7818227-7837064 bp, - strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172843
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. A floxed hygro cassette was inserted downstream of exon 1. (J:172843)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Birc2 Mutation:  6 strains or lines available
Notes
This allele was originally generated in ES cells containing Birc3tm1Rbr.
References
Original:  J:172843 Gardam S, et al., Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011 Apr 14;117(15):4041-51
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory