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Panx1tm1.2Vmd
Targeted Allele Detail
Nomenclature
Symbol: Panx1tm1.2Vmd
Name: pannexin 1; targeted mutation 1.2, Vishva M Dixit
MGI ID: MGI:5013648
Gene: Panx1  Location: Chr9:15005785-15045478 bp, - strand  Genetic Position: Chr9, 4.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173213
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette, and cre-mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on muscle, lung, liver, spleen, kidney, tail, brain, heart, thymus, and bone marrow-derived macrophage extracts. (J:173213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Panx1 Mutation:  4 strains or lines available
References
Original:  J:173213 Qu Y, et al., Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation. J Immunol. 2011 Jun 1;186(11):6553-61
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory