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Cop1tm1.1Vmd
Targeted Allele Detail
Summary
Symbol: Cop1tm1.1Vmd
Name: COP1, E3 ubiquitin ligase; targeted mutation 1.1, Vishva M Dixit
MGI ID: MGI:5013593
Synonyms: Cop1delta1
Gene: Cop1  Location: Chr1:159059890-159175210 bp, + strand  Genetic Position: Chr1, 69.03 cM, cytoband C3
Alliance: Cop1tm1.1Vmd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172653
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a lacZ reporter gene and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:172653)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cop1 Mutation:  43 strains or lines available
References
Original:  J:172653 Vitari AC, et al., COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 Jun 16;474(7351):403-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory