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Pax9tm1.1(Osr2)Jian
Targeted Allele Detail
Nomenclature
Symbol: Pax9tm1.1(Osr2)Jian
Name: paired box 9; targeted mutation 1.1, Rulang Jiang
MGI ID: MGI:5013428
Synonyms: Pax9del
Gene: Pax9  Location: Chr12:56691767-56712707 bp, + strand  Genetic Position: Chr12, 24.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173121
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Pax9tm1.1(Osr2)Jian expresses 1 gene
 
Mutation detailsA loxP site was inserted into exon 1 upstream of the ATG. A cassette containing (5' to 3') a loxP site, an FRT-flanked neo resistance marker, and a myc-tagged Osr2 cDNA with a polyadenylation sequence was inserted downstream of exon 2. Cre-mediated recombination removed part of exon 1 and all of exon 2. (J:173121)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax9 Mutation:  1 strain or line available
References
Original:  J:173121 Zhou J, et al., Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory