Ttn^tm3.1Mgot
Targeted Allele Detail

Summary

• Symbol: Ttn^tm3.1Mgot
• Name: titin; targeted mutation 3.1, Michael Gotthardt
• MGI ID: MGI:5013398
• Synonyms: titin-eGFP, Ttn^RECf
• Gene: Ttn Location: Chr2:76534324-76812891 bp, - strand Genetic Position: Chr2, 45.13 cM, cytoband D
• Alliance: Ttn^tm3.1Mgot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172357
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4 fused to EGFP. Flp-mediated recombination removed the neo cassette. (J:172357)

Generation of the Ttn^tm3.1Mgot allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttn Mutation: 1455 strains or lines available

References

• Original: J:172357 da Silva Lopes K, et al., Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres. J Cell Biol. 2011 May 16;193(4):785-98
• All: 3 reference(s)