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Adam8tm1.1Rood
Targeted Allele Detail
Nomenclature
Symbol: Adam8tm1.1Rood
Name: a disintegrin and metallopeptidase domain 8; targeted mutation 1.1, G David Roodman
MGI ID: MGI:5009706
Gene: Adam8  Location: Chr7:139978932-139992562 bp, - strand  Genetic Position: Chr7, 84.96 cM, cytoband F3-F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172936
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of eoxn 6. A floxed neo cassette was inserted downstream of exon 17. Cre-mediated recombination removed the neo cassette and exons 6 through 17. The absence of transcript expression was confirmed by semi-quantitative RT-PCR. (J:172936)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam8 Mutation:  17 strains or lines available
References
Original:  J:172936 Ishizuka H, et al., ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo. J Bone Miner Res. 2011 Jan;26(1):169-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory