Shox2^{tm2.1(SHOX_a)Ypc}
Targeted Allele Detail

Summary

• Symbol: Shox2^{tm2.1(SHOX_a)Ypc}
• Name: SHOX homeobox 2; targeted mutation 2.1, YiPing Chen
• MGI ID: MGI:5009258
• Synonyms: Shox2^KI
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^{tm2.1(SHOX_a)Ypc} page

Shox2^{tm2.1(SHOX_a)Ypc}/Shox2^{tm2.1(SHOX_a)Ypc} mice develop a severe wasting syndrome

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172674
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2, including the start codon, were replaced with a full length human SHOX_a cDNA and an FRT flanked neo cassette via homologous recombination. Flp mediated recombination removed the neo cassette. (J:172674)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 19 strains or lines available

References

• Original: J:172674 Liu H, et al., Functional Redundancy between Human SHOX and Mouse Shox2 Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function. J Biol Chem. 2011 May 13;286(19):17029-38
• All: 2 reference(s)