Shox2tm2(SHOX_a)Ypc
Targeted Allele Detail
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Symbol: |
Shox2tm2(SHOX_a)Ypc |
Name: |
SHOX homeobox 2; targeted mutation 2, YiPing Chen |
MGI ID: |
MGI:5009257 |
Synonyms: |
Shox2KI+Neo |
Gene: |
Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
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Alliance: |
Shox2tm2(SHOX_a)Ypc page
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Small size of Shox2tm2(SHOX_a)Ypc/Shox2tm2(SHOX_a)Ypc pups
Show the 2 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 1 and 2, including the start codon, were replaced with a full length human SHOX_a cDNA and an FRT flanked neo cassette via homologous recombination. RT_PCR analysis indicates that the presence of the neo cassette reduced expression of the human gene compared to mice with the neo cassette deleted.
(J:172674)
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Generation of the Shox2tm2(SHOX_a)Ypc allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Shox2 Mutation: |
19 strains or lines available
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Original: |
J:172674 Liu H, et al., Functional Redundancy between Human SHOX and Mouse Shox2 Genes in the Regulation of Sinoatrial Node Formation and Pacemaking Function. J Biol Chem. 2011 May 13;286(19):17029-38 |
All: |
1 reference(s) |
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