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Adamts4tm1.1Boer
Targeted Allele Detail
Nomenclature
Symbol: Adamts4tm1.1Boer
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; targeted mutation 1.1, Derek Boerboom
MGI ID: MGI:5009124
Synonyms: Adamts4-
Gene: Adamts4  Location: Chr1:171250421-171260637 bp, + strand  Genetic Position: Chr1, 79.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172645
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exons 2 and 3. (J:172645)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts4 Mutation:  20 strains or lines available
References
Original:  J:172645 Boerboom D, et al., Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul;240(7):1806-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory