About   Help   FAQ
Transgene Detail
Symbol: Tg(PDGFB-UCHL1*I93M)HWada
Name: transgene insertion H, Keiji Wada
MGI ID: MGI:5008738
Synonyms: H-hI93M, hUCHL1I93M
Transgene: Tg(PDGFB-UCHL1*I93M)HWada  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PDGFB-UCHL1*I93M)HWada expresses 1 gene
Mutation detailsThe human PDGFB promoter drives expression of a human UCHL1 cDNA with an isoleucine to methionine mutation at amino acid 93(I93M). Two lines were generated. Line L had lower levels of transgene expression compared to line H. Expression of the transgene is detected in the many brain regions including the substantia nigra, subthalamic nuclei, striatum, hippocampus CA3 and cerebellum. (J:128045)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:128045 Setsuie R, et al., Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int. 2007 Jan;50(1):119-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory