Tg(PDGFB-UCHL1*I93M)HWada
Transgene Detail
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Symbol: |
Tg(PDGFB-UCHL1*I93M)HWada |
Name: |
transgene insertion H, Keiji Wada |
MGI ID: |
MGI:5008738 |
Synonyms: |
H-hI93M, hUCHL1I93M |
Transgene: |
Tg(PDGFB-UCHL1*I93M)HWada Location: unknown
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Alliance: |
Tg(PDGFB-UCHL1*I93M)HWada page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(PDGFB-UCHL1*I93M)HWada expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
UCHL1 (7345) |
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Mutation details: The human PDGFB promoter drives expression of a human UCHL1 cDNA with an isoleucine to methionine mutation at amino acid 93(I93M). Two lines were generated. Line L had lower levels of transgene expression compared to line H. Expression of the transgene is detected in the many brain regions including the substantia nigra, subthalamic nuclei, striatum, hippocampus CA3 and cerebellum.
(J:128045)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:128045 Setsuie R, et al., Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int. 2007 Jan;50(1):119-29 |
All: |
2 reference(s) |
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