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Targeted Allele Detail
Symbol: Pkd2l1tm1.1Yuni
Name: polycystic kidney disease 2-like 1; targeted mutation 1.1, Yuzo Ninomiya
MGI ID: MGI:5008611
Gene: Pkd2l1  Location: Chr19:44147637-44192442 bp, - strand  Genetic Position: Chr19, 36.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:172581
Parent Cell Line:  EF1 (ES Cell)
Strain of Origin:  129S/SvEv x C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 9 were replaced with an IRES-mCherry and self-excising neo cassette. The neo cassette removed itself. No fluorescence expression was observed. Immunohistochemistry confirmed the absences of protein expression in taste tissue. (J:172581)
Generation of the Pkd2l1tm1.1Yuni allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkd2l1 Mutation:  3 strains or lines available
Original:  J:172581 Horio N, et al., Sour Taste Responses in Mice Lacking PKD Channels. PLoS One. 2011;6(5):e20007
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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