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Pkd2l1tm1.1Yuni
Targeted Allele Detail
Nomenclature
Symbol: Pkd2l1tm1.1Yuni
Name: polycystic kidney disease 2-like 1; targeted mutation 1.1, Yuzo Ninomiya
MGI ID: MGI:5008611
Gene: Pkd2l1  Location: Chr19:44147637-44192442 bp, - strand  Genetic Position: Chr19, 36.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172581
Parent Cell Line:  EF1 (ES Cell)
Strain of Origin:  129S/SvEv x C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 9 were replaced with an IRES-mCherry and self-excising neo cassette. The neo cassette removed itself. No fluorescence expression was observed. Immunohistochemistry confirmed the absences of protein expression in taste tissue. (J:172581)
Generation of the Pkd2l1tm1.1Yuni allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkd2l1 Mutation:  3 strains or lines available
References
Original:  J:172581 Horio N, et al., Sour Taste Responses in Mice Lacking PKD Channels. PLoS One. 2011;6(5):e20007
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory