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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Merck Research Laboratory
MGI ID: MGI:5007772
Synonyms: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1,CAG-tetR)Mrl, Rosa26PDK1-RNAi
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:170965
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Inducible, Knockdown)
Mutation:    Insertion
Mutation detailsA construct containing a short hairpin RNA targeting Pdpk1 driven by the H1/tetO operator fusion promoter and a floxed CAG promoter driving expression of the tetR regulatory cassette was inserted into the locus. (J:170965)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  290 strains or lines available
Original:  J:170965 Ellwood-Yen K, et al., PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models. Cancer Res. 2011 Apr 15;71(8):3052-65
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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