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C1qtnf2tm1Lex
Targeted Allele Detail
Summary
Symbol: C1qtnf2tm1Lex
Name: C1q and tumor necrosis factor related protein 2; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID: MGI:5007036
Gene: C1qtnf2  Location: Chr11:43365103-43382352 bp, + strand  Genetic Position: Chr11, 25.72 cM, cytoband B1.1
Alliance: C1qtnf2tm1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171883
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA portion of the coding region was targeted by homologous recombination. The entire exon 3 (260 bp) was replaced with a targeting cassette containing the beta-gal reporter gene, lacZ, followed by a floxed neomycin resistance cassette. Real-time PCR analysis confirmed the absence of mRNA expression in epididymal white adipose tissue (eWAT) of homozygous mutant mice. (J:171883, J:282612)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any C1qtnf2 Mutation:  22 strains or lines available
Notes
See also, data as provided by Lexicon Genetics, Inc.
References
Original:  J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory