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Pak2tm1Rjak
Targeted Allele Detail
Summary
Symbol: Pak2tm1Rjak
Name: p21 (RAC1) activated kinase 2; targeted mutation 1, Rolf Jakobi
MGI ID: MGI:5006977
Synonyms: PAK-2D212N-Neo+
Gene: Pak2  Location: Chr16:31835108-31898160 bp, - strand  Genetic Position: Chr16, 22.4 cM
Alliance: Pak2tm1Rjak page
Pak2tm1Rjak/Pak2tm1Rjak embryos are smaller and less developed

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171914
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitutions in exon 7 result in the amino acid substitution of asparagine for aspartic acid at position 212 (D212N). A floxed neo cassette was inserted downstream of the modified exon 7. The absence of protein expression was confirmed by western blot analysis. (J:171914)
Generation of the Pak2tm1Rjak allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pak2 Mutation:  62 strains or lines available
References
Original:  J:171914 Marlin JW, et al., Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34. Mamm Genome. 2011 Jun;22(5-6):306-17
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory