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Tg(Mov1/Tyr)OVE876BPay
Transgene Detail
Nomenclature
Symbol: Tg(Mov1/Tyr)OVE876BPay
Name: transgene insertion OVE876B, Richard Paylor
MGI ID: MGI:5006860
Synonyms: MALTT, multiple autistic-like trait transgenic
Transgene: Tg(Mov1/Tyr)OVE876BPay  Location: unknown  Genetic Position: ChrX, Syntenic
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsSequences from the 5' end of the Moloney murine leukemia virus were linked to a tyrosinase minigene consisting of a 2.1-kb promoter linked to a 1.9-kb tyrosinase cDNA. Expression of the tyrosinase minigene leads to melanin synthesis in the skin and fur. The transgene inserted in the non-coding region between Gm732 and Brwd3 on chromosome X. PCR amplification with minigene-only primer sets suggests that at minimum 2 copies inserted in tandem, while Southern blot hybridization indicates a maximum of 4 copies inserted together. Expression of Fam46d, located near the site of transgenic intergration, is upregulated. (J:167614)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:167614 Hamilton SM, et al., Multiple autism-like behaviors in a novel transgenic mouse model. Behav Brain Res. 2011 Mar 17;218(1):29-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory