About   Help   FAQ
Transgene Detail
Symbol: Tg(Mov1/Tyr)OVE876BPay
Name: transgene insertion OVE876B, Richard Paylor
MGI ID: MGI:5006860
Synonyms: MALTT, multiple autistic-like trait transgenic
Transgene: Tg(Mov1/Tyr)OVE876BPay  Location: unknown  Genetic Position: ChrX, Syntenic
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Mov1/Tyr)OVE876BPay expresses 1 gene
Mutation detailsSequences from the 5' end of the Moloney murine leukemia virus were linked to a tyrosinase minigene consisting of a 2.1-kb promoter linked to a 1.9-kb tyrosinase cDNA. Expression of the tyrosinase minigene leads to melanin synthesis in the skin and fur. The transgene inserted in the non-coding region between Gm732 and Brwd3 on chromosome X. PCR amplification with minigene-only primer sets suggests that at minimum 2 copies inserted in tandem, while Southern blot hybridization indicates a maximum of 4 copies inserted together. Expression of Fam46d, located near the site of transgenic intergration, is upregulated. (J:167614)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:167614 Hamilton SM, et al., Multiple autism-like behaviors in a novel transgenic mouse model. Behav Brain Res. 2011 Mar 17;218(1):29-41
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory