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Rgs16tm1Tmw
Targeted Allele Detail
Nomenclature
Symbol: Rgs16tm1Tmw
Name: regulator of G-protein signaling 16; targeted mutation 1, Thomas M Wilkie
MGI ID: MGI:5004805
Gene: Rgs16  Location: Chr1:153740349-153745468 bp, + strand  Genetic Position: Chr1, 65.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172091
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. The absence of protein expression was confirmed by western blot analysis. (J:172091)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rgs16 Mutation:  9 strains or lines available
Notes
ES cell line = MJ-1
References
Original:  J:172091 Pashkov V, et al., Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner. J Biol Chem. 2011 Apr 29;286(17):15116-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory