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Tg(Hmgcr-PSEN1*M146L)#Lpr
Transgene Detail
Nomenclature
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr
Name: transgene insertion, Laurent Pradier
MGI ID: MGI:5003458
Synonyms: HMG-PS1M146L
Transgene: Tg(Hmgcr-PSEN1*M146L)#Lpr  Location: unknown  
Transgene
origin
Strain of Origin:  CBA x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Hmgcr-PSEN1*M146L)#Lpr expresses 1 gene
 
Mutation detailsThe murine Hmgcr promoter drives expression a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L). (J:86694)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:86694 Blanchard V, et al., Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol. 2003 Nov;184(1):247-63
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory