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Raf1tm1.1Bgn
Targeted Allele Detail
Nomenclature
Symbol: Raf1tm1.1Bgn
Name: v-raf-leukemia viral oncogene 1; targeted mutation 1.1, Benjamin G Neel
MGI ID: MGI:5003364
Synonyms: Raf1L613V, Raf1tm1.1Ara
Gene: Raf1  Location: Chr6:115618067-115676635 bp, - strand  Genetic Position: Chr6, 53.62 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172034
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCr)F1
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Raf1 Mutation:  88 strains or lines available
References
Original:  J:172034 Wu X, et al., MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. J Clin Invest. 2011 Mar 1;121(3):1009-25
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory