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Targeted Allele Detail
Symbol: Tdgf1tm2.2Mms
Name: teratocarcinoma-derived growth factor 1; targeted mutation 2.2, Michael M Shen
MGI ID: MGI:5002491
Synonyms: Cripto2loxP
Gene: Tdgf1  Location: Chr9:110768676-110775226 bp, - strand  Genetic Position: Chr9, 60.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:104418
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a loxP-flanked neomycin resistance (neo) cassette downstream of exon 5, and a single loxP site downstream of exon 2 of the teratocarcinoma-derived growth factor 1 (Tdgf1) gene. Cre-mediated recombination removed the neo cassette and left exons 3 through 5 floxed. (J:104418)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tdgf1 Mutation:  59 strains or lines available
Original:  J:104418 Chu J, et al., Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development. 2005 Dec;132(24):5539-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory