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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sean E Egan
MGI ID: MGI:5000472
Synonyms: R26-Pik3caH1047R
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:170898
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan expresses 1 gene
Mutation detailsA construct consisting of a splice acceptor site, a floxed transcriptional stop cassette and a mutant mouse Pik3ca cDNA, encoding for a histidine 1047 arginine substitution, was inserted into intron 1 via homologous recombination. (J:170898)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  253 strains or lines available
Original:  J:170898 Adams JR, et al., Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation. Cancer Res. 2011 Apr 1;71(7):2706-2717
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory