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Tg(tetO-TARDBP*)4Vle
Transgene Detail
Nomenclature
Symbol: Tg(tetO-TARDBP*)4Vle
Name: transgene insertion 4, Virginia M Y Lee
MGI ID: MGI:5000261
Synonyms: hTDP-43deltaNLS4
Transgene: Tg(tetO-TARDBP*)4Vle  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-TARDBP*)4Vle expresses 1 gene
 
Mutation detailsThe tetracycline responsive promoter drives inducible expression of the human cDNA lacking the nuclear localization signal. Two lines were generated (4 and 19). (J:170756)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:170756 Igaz LM, et al., Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb 1;121(2):726-38
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory