Boc^tm1Rsk
Targeted Allele Detail

Summary

• Symbol: Boc^tm1Rsk
• Name: BOC cell adhesion associated, oncogene regulated; targeted mutation 1, Robert S Krauss
• MGI ID: MGI:5000228
• Synonyms: Boc^-, Boc^AP-1
• Gene: Boc Location: Chr16:44305408-44379233 bp, - strand Genetic Position: Chr16, 28.81 cM, cytoband B5
• Alliance: Boc^tm1Rsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171767
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 540 bp region including the entire first coding exon was deleted and an IRES-hAP and floxed PGK-neo cassette was inserted in exon 2 via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous embryos. Alkaline phosphatase activity mirrors endogenous gene expression. (J:171767)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Boc Mutation: 61 strains or lines available

References

• Original: J:171767 Zhang W, et al., Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis Model Mech. 2011 May-Jun;4(3):368-80
• All: 4 reference(s)