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Boctm1Rsk
Targeted Allele Detail
Nomenclature
Symbol: Boctm1Rsk
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein; targeted mutation 1, Robert S Krauss
MGI ID: MGI:5000228
Synonyms: Boc-, BocAP-1
Gene: Boc  Location: Chr16:44485049-44558897 bp, - strand  Genetic Position: Chr16, 28.81 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171767
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 540 bp region including the entire first coding exon was deleted and an IRES-hAP and floxed PGK-neo cassette was inserted in exon 2 via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous embryos. Alkaline phosphatase activity mirrors endogenous gene expression. (J:171767)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Boc Mutation:  7 strains or lines available
References
Original:  J:171767 Zhang W, et al., Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis Model Mech. 2011 May-Jun;4(3):368-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory