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Targeted Allele Detail
Symbol: Kdm4btm1.2Okad
Name: lysine (K)-specific demethylase 4B; targeted mutation 1.2, Hitoshi Okada
MGI ID: MGI:4999585
Synonyms: Jmjd2bdelta
Gene: Kdm4b  Location: Chr17:56326062-56402870 bp, + strand  Genetic Position: Chr17, 29.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:171678
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed exon 5, which results in a frameshift and translation termination, and removal of H189 and E191 residues essential for demethylase activity. (J:171678)
Generation of the Kdm4btm1.1Okad and Kdm4btm1.2Okad alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm4b Mutation:  35 strains or lines available
Original:  J:171678 Kawazu M, et al., Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One. 2011;6(3):e17830
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory