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Kdm4btm1.2Okad
Targeted Allele Detail
Nomenclature
Symbol: Kdm4btm1.2Okad
Name: lysine (K)-specific demethylase 4B; targeted mutation 1.2, Hitoshi Okada
MGI ID: MGI:4999585
Synonyms: Jmjd2bdelta
Gene: Kdm4b  Location: Chr17:56326062-56402870 bp, + strand  Genetic Position: Chr17, 29.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171678
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 5, which results in a frameshift and translation termination, and removal of H189 and E191 residues essential for demethylase activity. (J:171678)
Generation of the Kdm4btm1.1Okad and Kdm4btm1.2Okad alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm4b Mutation:  35 strains or lines available
References
Original:  J:171678 Kawazu M, et al., Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One. 2011;6(3):e17830
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory