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Tg(PDGFB-LRRK2*G2019S)340Djmo
Transgene Detail
Nomenclature
Symbol: Tg(PDGFB-LRRK2*G2019S)340Djmo
Name: transgene insertion 340, Darren Moore
MGI ID: MGI:4950671
Synonyms: G2019S-LRRK2
Transgene: Tg(PDGFB-LRRK2*G2019S)340Djmo  Location: unknown  
Progressive loss of substantia nigra dopaminergic neurons in Tg(PDGFB-LRRK2*G2019S)340Djmo/0 transgenic mice

Show the 6 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PDGFB-LRRK2*G2019S)340Djmo expresses 1 gene
 
Mutation detailsThe G2019S-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a full length human leucine-rich repeat kinase 2 (LRRK2) cDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 340 was generated. (J:171645)
Schematic of the Tg(PDGFB-LRRK2*G2019S)340Djmo or Tg(PDGFB-LRRK2*R1441C)574Djmo transgene
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:171645 Ramonet D, et al., Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2. PLoS One. 2011;6(4):e18568
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory