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Targeted Allele Detail
Symbol: Abi1tm1.2Lko
Name: abl-interactor 1; targeted mutation 1.2, Leszek Kotula
MGI ID: MGI:4950558
Gene: Abi1  Location: Chr2:22940073-23040241 bp, - strand  Genetic Position: Chr2, 15.18 cM
Exencephaly and pericardial edema in Abi1tm1.2Lko/Abi1tm1.2Lko embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:171342
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site was inserted 5' of exon 1 and a floxed and FRT flanked neo cassette was inserted 3' of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. Cre mediated recombination removed exon 1. (J:171342)
Generation of the Abi1tm1.1Lko and Abi1tm1.2Lko alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abi1 Mutation:  71 strains or lines available
Original:  J:171342 Dubielecka PM, et al., Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory