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Otoftm1.1Erei
Targeted Allele Detail
Nomenclature
Symbol: Otoftm1.1Erei
Name: otoferlin; targeted mutation 1.1, Ellen Reisinger
MGI ID: MGI:4950055
Gene: Otof  Location: Chr5:30367062-30461932 bp, - strand  Genetic Position: Chr5, 16.48 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171203
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced exons 14 and 15. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by immunohistochemistry on cochlea samples. (J:171203)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otof Mutation:  63 strains or lines available
References
Original:  J:171203 Reisinger E, et al., Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis. J Neurosci. 2011 Mar 30;31(13):4886-4895
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory