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Targeted Allele Detail
Symbol: Ntrk3tm1.1Tes
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1.1, Lino Tessarollo
MGI ID: MGI:4950053
Synonyms: TrkC.T1-
Gene: Ntrk3  Location: Chr7:77825711-78228865 bp, - strand  Genetic Position: Chr7, 44.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:171397
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 13b and a floxed ura/neomycin selection cassette was placed downstream of exon 14b. Cre expression results in removal of 2.5kb of sequence including both exons 13b and 14b. The deleted locus can no longer express the TrkC.T1 isoform. Full length product is expressed at a level of 1.6X normal however. (J:171397)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:  47 strains or lines available
Original:  J:171397 Bai Y, et al., In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6639-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory