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Neat1tm1.1Shna
Targeted Allele Detail
Nomenclature
Symbol: Neat1tm1.1Shna
Name: nuclear paraspeckle assembly transcript 1 (non-protein coding); targeted mutation 1.1, Shinichi Nakagawa
MGI ID: MGI:4949933
Synonyms: NEAT1lacZ
Gene: Neat1  Location: Chr19:5824708-5845478 bp, - strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171281
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA lacZ and FRT flanked neo cassette was inserted immediately downstream of the transcription start site via homologous recombination. Flp mediated recombination removed the neo cassette. Quantitative PCR analysis indicates that expression of the short transcript is decreased to about 6% of wild-type and expression of the long transcript is absent in MEFs from homozygous mice. (J:171281)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neat1 Mutation:  218 strains or lines available
References
Original:  J:171281 Nakagawa S, et al., Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 2011 Apr 4;193(1):31-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory