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Targeted Allele Detail
Symbol: Neat1tm1.1Shna
Name: nuclear paraspeckle assembly transcript 1 (non-protein coding); targeted mutation 1.1, Shinichi Nakagawa
MGI ID: MGI:4949933
Synonyms: NEAT1lacZ
Gene: Neat1  Location: Chr19:5874736-5895506 bp, - strand  Genetic Position: Chr19, 4.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:171281
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA lacZ and FRT flanked neo cassette was inserted immediately downstream of the transcription start site via homologous recombination. Flp mediated recombination removed the neo cassette. Quantitative PCR analysis indicates that expression of the short transcript is decreased to about 6% of wild-type and expression of the long transcript is absent in MEFs from homozygous mice. (J:171281)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neat1 Mutation:  221 strains or lines available
Original:  J:171281 Nakagawa S, et al., Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 2011 Apr 4;193(1):31-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory