About   Help   FAQ
Shank3tm2Gfng
Targeted Allele Detail
Summary
Symbol: Shank3tm2Gfng
Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 2, Guoping Feng
MGI ID: MGI:4949738
Synonyms: Shank3B-, Shank3/F
Gene: Shank3  Location: Chr15:89383826-89444464 bp, + strand  Genetic Position: Chr15, 44.96 cM
Alliance: Shank3tm2Gfng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171113
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence from exons 13 through 16, which encode the PDZ domain, was replaced with a neo cassette. The absence of alpha and beta isoform expression and reduced gamma isoform expression were confirmed by western blot analysis on brain extracts. (J:171113)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shank3 Mutation:  77 strains or lines available
References
Original:  J:171113 Peca J, et al., Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011 Apr 28;472(7344):437-42
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory