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Cacna1atm1.1Sher
Targeted Allele Detail
Nomenclature
Symbol: Cacna1atm1.1Sher
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1.1, Stefan Herlitze
MGI ID: MGI:4949728
Synonyms: Cacna1aCitrine, Cacna1atm-Citrine+
Gene: Cacna1a  Location: Chr8:84388440-84640246 bp, + strand  Genetic Position: Chr8, 40.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170451
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette, which contained (5' to 3') a loxP site, citrine reporter, duplicate exon 1, second loxP site, neo cassette, and third loxP site, was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette while the floxed citrine reporter and duplicate exon 1 remain intact. (J:170451)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1a Mutation:  41 strains or lines available
References
Original:  J:170451 Mark MD, et al., Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci. 2011 Mar 16;31(11):4311-26
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory