Pikfyve^tm1.1Ashi
Targeted Allele Detail

Summary

• Symbol: Pikfyve^tm1.1Ashi
• Name: phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 1.1, Assia Shisheva
• MGI ID: MGI:4949700
• Synonyms: PIKfyve^fl, PIKfyve^fldeltaneo, PIKfyve^flox
• Gene: Pikfyve Location: Chr1:65225842-65317854 bp, + strand Genetic Position: Chr1, 32.94 cM, cytoband C3
• Alliance: Pikfyve^tm1.1Ashi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171129
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:171129)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pikfyve Mutation: 114 strains or lines available

References

• Original: J:171129 Ikonomov OC, et al., The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development: PREIMPLANTATION LETHALITY OF PIKfyve-/- EMBRYOS BUT NORMALITY OF PIKfyve+/- MICE. J Biol Chem. 2011 Apr 15;286(15):13404-13
• All: 6 reference(s)