About   Help   FAQ
Rhebtm1.1Yelg
Targeted Allele Detail
Summary
Symbol: Rhebtm1.1Yelg
Name: Ras homolog enriched in brain; targeted mutation 1.1, Ype Elgersma
MGI ID: MGI:4949062
Gene: Rheb  Location: Chr5:25007821-25047359 bp, - strand  Genetic Position: Chr5, 11.93 cM
Alliance: Rhebtm1.1Yelg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170999
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced a portion of the 5'UTR, and exon 3 was flanked by loxP sites. Cre-mediated recombination removed the neo cassette and exon 3. The absences of protein expression was confirmed by western blot analysis on E11.5 whole embryo extracts (J:170999)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rheb Mutation:  26 strains or lines available
References
Original:  J:170999 Goorden SM, et al., Rheb is essential for murine development. Mol Cell Biol. 2011 Apr;31(8):1672-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory