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Myh14tm2Rsad
Targeted Allele Detail
Nomenclature
Symbol: Myh14tm2Rsad
Name: myosin, heavy polypeptide 14; targeted mutation 2, Robert S Adelstein
MGI ID: MGI:4948885
Synonyms: 2CR722C
Gene: Myh14  Location: Chr7:44605803-44670843 bp, - strand  Genetic Position: Chr7, 28.85 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:171110
Parent Cell Line:  CMT-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsThe targeting vector was designed to change arginine to cysteine at amino acid position 722 (R722C) by substituting CGC for TGC in exon 17. A loxP-flanked pGK neomycin cassette was also inserted in the intron. Cre mediated recombination removed the neo cassette. (J:171110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh14 Mutation:  51 strains or lines available
References
Original:  J:171110 Adelstein RS, Generation of a Myh14 knockin with an R722C substitution. MGI Direct Data Submission. 2011;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory