About   Help   FAQ
Cdc14btm1.2Pzg
Targeted Allele Detail
Summary
Symbol: Cdc14btm1.2Pzg
Name: CDC14 cell division cycle 14B; targeted mutation 1.2, Pumin Zhang
MGI ID: MGI:4948253
Synonyms: Cdc14bdeltaE2
Gene: Cdc14b  Location: Chr13:64337082-64423104 bp, - strand  Genetic Position: Chr13, 33.26 cM
Alliance: Cdc14btm1.2Pzg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170763
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 2 and the neo cassette. RT-PCR confirmed the expression of two truncated transcripts that are not predicted to produce a functional protein. (J:170763)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc14b Mutation:  38 strains or lines available
References
Original:  J:170763 Wei Z, et al., Early-onset aging and defective DNA damage response in cdc14b-deficient mice. Mol Cell Biol. 2011 Apr;31(7):1470-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory