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Tg(NEFH)398Jpj
Transgene Detail
Nomenclature
Symbol: Tg(NEFH)398Jpj
Name: transgene insertion 398, Jean-Pierre Julien
MGI ID: MGI:4947051
Synonyms: NF-H44
Transgene: Tg(NEFH)398Jpj  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe genomic fragments containing the human NEFH gene, flanked by 5'-promoter region and 3' sequences, coding for 44 Lys-Ser-Pro (KSP) phosphorylation sites, was used for the transgene. The total amount of protein detected in cytoskeletal-enriched preparations of the spinal cord corresponds to about two-fold the level detected in normal mice as determined by Coomassie blue after SDS/PAGE. (J:69179)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:69179 Couillard-Despres S, et al., Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9626-30
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory