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Lig3tm1.1Pmc
Targeted Allele Detail
Nomenclature
Symbol: Lig3tm1.1Pmc
Name: ligase III, DNA, ATP-dependent; targeted mutation 1.1, Peter J McKinnon
MGI ID: MGI:4946931
Synonyms: Lig3c, Lig3LoxP
Gene: Lig3  Location: Chr11:82781109-82804274 bp, + strand  Genetic Position: Chr11, 50.23 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170077
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted downstream of exon 5 and upstream of exon 15. An FRT-flanked neo cassette was removed by flp-mediated recombination. (J:170077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lig3 Mutation:  28 strains or lines available
References
Original:  J:170077 Gao Y, et al., DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature. 2011 Mar 10;471(7337):240-4
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory