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Targeted Allele Detail
Symbol: Tcf7l2tm2.2Mrc
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.2, Mario R Capecchi
MGI ID: MGI:4946911
Synonyms: Tcf4delta
Gene: Tcf7l2  Location: Chr19:55741820-55933654 bp, + strand  Genetic Position: Chr19, 51.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:170088
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed exon 1 from Tcf7l2tm2.1Mrc. The absence of protein expression was confirmed by immunohistochemistry on E16.5 small intestine and colon samples. (J:170088)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  35 strains or lines available
Original:  J:170088 Angus-Hill ML, et al., T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4914-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory