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Artm3.1(AR)Ska
Targeted Allele Detail
Nomenclature
Symbol: Artm3.1(AR)Ska
Name: androgen receptor; targeted mutation 3.1, Shigeaki Kato
MGI ID: MGI:4946660
Synonyms: ARflox, ArL2
Gene: Ar  Location: ChrX:98149721-98323215 bp, + strand  Genetic Position: ChrX, 42.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170092
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 through 8 were replaced with a floxed cDNA of the corresponding human sequence, a neo cassette with a 3' loxP site, and a cDNA of the corresponding human sequence with nucleotide substitutions that result in the amino acid substitution of alanine for threonine at position 877. Cre-mediated recombination removed the neo cassette. (J:170092)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  20 strains or lines available
References
Original:  J:170092 Takahashi S, et al., Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4938-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory