Ar^tm3.1(AR)Ska
Targeted Allele Detail

Summary

• Symbol: Ar^tm3.1(AR)Ska
• Name: androgen receptor; targeted mutation 3.1, Shigeaki Kato
• MGI ID: MGI:4946660
• Synonyms: AR^flox, Ar^L2
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm3.1(AR)Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170092
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Ar^tm3.1(AR)Ska expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: Exons 6 through 8 were replaced with a floxed cDNA of the corresponding human sequence, a neo cassette with a 3' loxP site, and a cDNA of the corresponding human sequence with nucleotide substitutions that result in the amino acid substitution of alanine for threonine at position 877. Cre-mediated recombination removed the neo cassette. (J:170092)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 22 strains or lines available

References

• Original: J:170092 Takahashi S, et al., Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4938-43
• All: 1 reference(s)