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Targeted Allele Detail
Symbol: Tdrd5tm1Sait
Name: tudor domain containing 5; targeted mutation 1, Mitinori Saitou
MGI ID: MGI:4946629
Gene: Tdrd5  Location: Chr1:156255296-156303664 bp, - strand  Genetic Position: Chr1, 67.71 cM, cytoband G3
Sterility in Tdrd5tm1Sait/Tdrd5tm1Sait males

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:170319
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced exons 10 and 11. The absence of protein expression was confirmed by western blot analysis on testes extract. (J:170319)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tdrd5 Mutation:  30 strains or lines available
Original:  J:170319 Yabuta Y, et al., TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory