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Hic1tm1.2Kori
Targeted Allele Detail
Nomenclature
Symbol: Hic1tm1.2Kori
Name: hypermethylated in cancer 1; targeted mutation 1.2, Vladimir Korinek
MGI ID: MGI:4946619
Synonyms: Hic1delEx2
Gene: Hic1  Location: Chr11:75164565-75169519 bp, - strand  Genetic Position: Chr11, 45.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170337
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the coding region of exon 2. The absence of protein expression was confirmed by western blot analysis. (J:170337)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hic1 Mutation:  13 strains or lines available
References
Original:  J:170337 Pospichalova V, et al., Generation of two modified mouse alleles of the Hic1 tumor suppressor gene. Genesis. 2011 Mar;49(3):142-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory