Prdm1^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Prdm1^tm1Mbu
• Name: PR domain containing 1, with ZNF domain; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:4946616
• Synonyms: Blimp1^Bio, Prdm1^Bio
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170323
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: A FLAG-V5-TEV cleavage site-biotin tag construct, an FRT flanked IRES-CD2 reporter construct and a loxP flanked pgk-neo cassette were inserted in the end of exon 8 via homologous recombination. Recombinase mediated recombination removed the reporter and neo cassettes. (J:170323, J:259465)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 64 strains or lines available

References

• Original: J:170323 Cretney E, et al., The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol. 2011 Apr;12(4):304-11
• All: 4 reference(s)