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Tg(Adipoq-cre/ERT2)1Soff
Transgene Detail
Nomenclature
Symbol: Tg(Adipoq-cre/ERT2)1Soff
Name: transgene insertion 1, Stefan Offermanns
MGI ID: MGI:4946615
Synonyms: Adipoq creER(T)2, AdipoqCreERT2
Transgene: Tg(Adipoq-cre/ERT2)1Soff  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting vector containing cDNA encoding cre recombinase fused to the mutated form of the ligand binding domain of the human estrogen receptor followed by an Frt-flanked ampicillin resistance marker was generated. Homologous recombination resulted in insertion of the vector into the start codon of the Adipoq locus present in a BAC clone (RP23-112M7; this BAC also contained the genes Kng1, Eif4a2, and Rfc4.) Flp-mediated excision removed the ampicillin marker. Five founders were obtained and crossed with lacZ reporter mice. Progeny of one founder displayed homogeneous lacZ expression in epididymal, mesenterial, and retroperitoneal white adipose tissue after tamoxifen treatment. (J:170002)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Adipoq     Summary of all recombinase alleles driven by Adipoq. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:170002 Sassmann A, et al., Tamoxifen-inducible Cre-mediated recombination in adipocytes. Genesis. 2010 Oct 1;48(10):618-25
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory