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Aqp4tm1.1Lmno
Targeted Allele Detail
Nomenclature
Symbol: Aqp4tm1.1Lmno
Name: aquaporin 4; targeted mutation 1.1, Laboratory for Molecular Neuroscience
MGI ID: MGI:4946403
Gene: Aqp4  Location: Chr18:15389496-15410982 bp, - strand  Genetic Position: Chr18, 8.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168686
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exons 1 through 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:168686)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp4 Mutation:  29 strains or lines available
References
Original:  J:168686 Thrane AS, et al., Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory