Dstn^tm1.1Wit
Targeted Allele Detail

Summary

• Symbol: Dstn^tm1.1Wit
• Name: destrin; targeted mutation 1.1, Walter Witke
• MGI ID: MGI:4943283
• Synonyms: ADF-
• Gene: Dstn Location: Chr2:143757251-143785244 bp, + strand Genetic Position: Chr2, 70.89 cM, cytoband H1
• Alliance: Dstn^tm1.1Wit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125317
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and floxed neo cassette were inserted into exon 2. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:125317)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dstn Mutation: 43 strains or lines available

References

• Original: J:125317 Bellenchi GC, et al., N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007 Sep 15;21(18):2347-57
• All: 6 reference(s)