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Dstntm1.1Wit
Targeted Allele Detail
Nomenclature
Symbol: Dstntm1.1Wit
Name: destrin; targeted mutation 1.1, Walter Witke
MGI ID: MGI:4943283
Synonyms: ADF-
Gene: Dstn  Location: Chr2:143915331-143943324 bp, + strand  Genetic Position: Chr2, 70.89 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125317
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ and floxed neo cassette were inserted into exon 2. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:125317)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dstn Mutation:  22 strains or lines available
References
Original:  J:125317 Bellenchi GC, et al., N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007 Sep 15;21(18):2347-57
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory